Inhalation or total intravenous anaesthesia and recurrence after colorectal cancer surgery: a propensity score matched Danish registry-based study

BackgroundDuring colorectal cancer surgery, the immune-modulating effects of inhalation anaesthesia may create a favourable environment for metastasis formation, leading to increased risk recurrence. Our aim was assess association between vs intravenous and recurrence in patients undergoing surgery.MethodsPatients surgery 2004–18 were identified Danish Colorectal Cancer Group Database Anaesthesia Database. After exclusion with residual tumour registered postoperative pathology reports, local endoscopic resections, stent insertions, we classified according exposure anaesthesia. The primary outcome (time recurrence), whereas secondary outcomes all-cause mortality death) disease-free survival either or death). Events death using Civil Registration System, National Pathology Registry, Patient Registry. sub-distribution hazards approach used estimate hazard ratios (HRs) recurrence, Cox regression survival.ResultsWe 5238 exposed 6322 Propensity score matching yielded 4347 individuals each group balanced baseline covariates. We found weak (HR=1.12; 95% confidence interval [CI], 1.02–1.23). HR estimates 1.00 (95% CI, 0.93–1.07) 1.04 0.98–1.11) respectively.ConclusionExposure associated after surgery.